As Thor: Ragnarok seemingly established, Hulk is the "strongest Avenger," so the fact that Thanos is even stronger than him is certainly a bit of a concern for Earth's Mightiest Heroes. Thanos then meets the Fallen One, revealed to be the true first Herald of Galactus. While the World Breaker Hulk and Thanos are both powerhouses, this Hulk will always overpower Thanos, assuming he doesn't have the Infinity Gauntlet. Thanos defeats the former Herald and places him under complete mental control. Both Thanos and Hulk can take a licking and keep on ticking, so their intense strength wouldn't, at first, be enough. As the Annihilation War began, Death suggested that Thanos and Annihilus should team up. Is World Breaker Hulk Stronger Than Thanos?
Adam Warlock, who was teased in Guardians of the Galaxy Vol 2 and will likely appear in Vol 3, then uses his connection to the Soul World (the world inside the Soul Stone) and acquires the Infinity Gauntlet for himself as Nebula battles and defeats the Cosmic Entities. Avengers 4: Thanos will be defeated by THIS devastating blow - Guess who is the key? AVENGERS 4 villain will not be defeated by Iron Man, Captain Marvel or any surviving Infinity War hero. In the opening of Avengers: Infinity War, Hulk takes on Thanos and it does not go well for Hulk. How Thanos Was Defeated In The Comic Book Version Updated: 28 Apr 2018 4:47 am Art by Jorge Fornes and Chris O’Halloran, from the cover of Marvel’s Avengers: Infinity War Prelude #2, 2018 In the end, Warlock finds out that Thanos is living as a farmer on an unknown planet. Thanos and his remaining children, collectively known as the Black Order, board the ship and kill half the remaining Asgardians. Thanos was able to easily wipe the floor with the Hulk and then kills Loki right in front of Thor.
In the aftermath of the slaughter, Thanos personally defeats the Hulk in hand-to-combat and kills Heimdall.
Using Moondragon's telepathic powers, She-Hulk essentially entered Thanos' mind in the following issue where she discovered that this was not the real Thanos, but rather a very special clone of Thanos. Thanos may have ultimately gotten his just desserts from the whole crew in Avengers: Endgame, but he could have tasted defeat at the hands of just one of … She-Hulk, though, felt that this was all too convenient. Thanos departs the Kyln in the company of Skreet, a chaos-mite freed from the prison. He takes the Space Stone from Loki and kills him, then leaves Thor to die.