Przemysl Chemiczny, 1, 32-35. (2005) Conversion of 2-Methylpropanal toward Aliphatic Solvents and Plasticizers for Polymers. Using weak anion-exchange resin, the optimal conversion of propanal was 89.9% after 24 h at 0.8 g/mL resin and 35 °C, and the main product was 3-hydroxy-2-methylpropanal by first cross-aldol condensation along with relatively minor amounts of methacrolein and 3-hydroxy-2-methyl-2-hydroxymethylpropanal. Aldol condensation reaction can be either acid catalyzed or base catalyzed. Chem. For each of the following aldol products (a through e) select a donor and an acceptor compound from the list at the bottom of the page (compounds A through H). Migues, A.N., Vaitheeswaran, S. and Auerbach, S.M. Am. In all experiments the reaction products consisted mainly of monoesters 3 and 4 and aldoxanes 5 and 6 , without substantial variations in proportions. The dehydration of the initial Aldol products can occur, it is often favoured by the following factors: The Aldol product must still have an α-hydrogen between the carbonyl and the -OH group. The more advanced topics are : Dehydration, Mixed and Intramolecular Aldol reactions. Summary. 1995 , 117 , 7585). Write the letter corresponding to your selection in the appropriate answer box. This reaction was thought to occur only with aldehydes. Soc. DERA, or 2-deoxyribose 5-phosphate aldolase, is an enzyme that catalyses C-C bond formation, often in a highly stereoselective way, and is the only enzyme that accepts more than one aldehyde in the condensation reaction ( J.

The compound you mentioned does undergo aldol addition, not condensation; I’ll tell you why. Remember enolates are good nucleophiles and carbonyl C are good electrophiles. (2014) Density Functional Theory Study of Mixed Aldol Condensation Catalyzed by Acidic Zeolites HZSM-5 and HY. My this context deals with the base catalyzed reaction of aldol condensation and its mechanism. Aldol reactions catalysed by enzymes are also important to mention. We used 2-methylpropanal 1 as a simple starting compound (aldol 2 contains only one stereogenic centre), and binaphtholates as chiral catalysts in solvents such as THF, DMF and DMSO. The first step of the process is a reaction between two 2-methylpropanal molecules, which runs according to the aldol condensation mechanism, whereby aldol, i.e. Aldol condensation proceeds by carbon-carbon bond formation between an enolate donor and a carbonyl acceptor. Tic, W.J. Reagents : commonly a base such as NaOH or KOH is added to the aldehyde. Firstly, the compound only has one alpha hydrogen, which will be extracted by the base during the aldol addition step. The Aldol Reaction of Aldehydes Reaction type : Nucleophilic addition. Dehydration of Aldol products. The reaction involves an aldehyde enolate reacting with another molecule of the aldehyde.